The MTC metoclopramide test is used in the diagnosis of hyperprolactinaemia, i.e. elevated serum prolactin levels. Hyperprolactinaemia can cause menstrual disorders, fertility problems, decreased libido or impotence. Before performing the metoclopramide test, it is recommended to verify that the elevated prolactin level is not caused by physiological factors, e.g. pregnancy.
How is the MTC metoclopramide test performed?
- Taking blood from the patient on an empty stomach to determine serum prolactin levels.
- Administering 10 mg of metoclopramide orally in the form of a tablet, delivered to the laboratory by the patient.
- Taking blood from the patient 60 minutes after administering a metoclopramide tablet and determining the serum prolactin level
- Repeat the steps from the third point 120 minutes after taking the tablet
The metoclopramide test is performed with serum prolactin levels up to 150 ng / ml. Due to the fact that prolactin is a hormone that is released in stress reactions, remember to relax before and during the test and avoid exposure to stressful situations if possible.
MTC metoclopramide test – the correct result is:
- Increase in prolactin concentration after 120 minutes up to 3-6 times based on the value obtained in the fasting state. Example: fasting prolactin 40 ng/ml – prolactin after 120 minutes – 160 ng/ml.
MTC metoclopramide test – the incorrect result is:
- A rise in prolactin levels greater than sixfold after 120 minutes may indicate the development of functional hyperprolactinaemia. Example: fasting prolactin 40 ng/ml – prolactin after 120 minutes – 280 ng/ml.
- Lack of changes in the level of prolactin after administration of metoclopramide may indicate the presence of a pituitary tumor (prolactinoma) or changes in the hypothalamic-pituitary region. Example: fasting prolactin 99 ng/ml – prolactin after 120 minutes – 103 ng/ml.
The metoclopramide test is an auxiliary test, medical history and imaging studies are necessary to complete a diagnosis. Remember to consult a doctor about all symptoms and doubts!
What is metoclopramide?
Metoclopramide is used to prevent nausea and vomiting from chemotherapy, cancer and migraines. This drug stimulates the secretion of prolactin and is therefore useful in the metoclopramide loading test.
Disclaimer: This page is for informational purposes only. Conversion rates have been compiled based on publicly available information. All information should be confirmed and verified. The data on the site is not a substitute for professional medical advice. Any information, result, conversion should be consulted with a doctor.